منابع مشابه
Endothelin Receptor Antagonism and Hypertonic Solutions in Experimental Endotoxin Shock
Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due to hypoperfusion and inflammatory changes. The supportive treatment includes fluid resuscitation and other measures to promote organ perfusion. Hypertonic saline/dextran (HSD...
متن کاملCardiac effects of endothelin receptor antagonism in endotoxemic pigs.
Myocardial depression in sepsis is frequently encountered clinically and contributes to morbidity and mortality. Increased plasma levels of endothelin-1 (ET-1) have been described in septic shock, and previous reports have shown beneficial effects on cardiovascular performance and survival in septic models using ET receptor antagonists. The aim of the current study was to investigate specific c...
متن کاملConfidence from experience: dual endothelin receptor antagonism in PAH
P ulmonary hypertension (PH) is classified into five logical treatment-based groups [1]. Pulmonary arterial hypertension (PAH) represents the first of these five groups and is further classified as idiopathic (predisposing factors having been excluded), familial or as occurring in association with certain conditions, including connective tissue disease, congenital heart disease and HIV infectio...
متن کاملDual endothelin receptor antagonism: setting standards in PAH
Endothelin (ET) has emerged as a key mediator in the pathophysiology of pulmonary arterial hypertension (PAH). The effects of ET are mediated by its binding to two receptors on endothelial and pulmonary smooth muscle cells: ETA and ETB. Blockade of both these receptors with the oral dual ET receptor antagonist, bosentan, represents an attractive treatment option for these severely compromised p...
متن کاملEndothelin receptor antagonism: what does the future hold?
The endothelins are a family (ET-1, ET-2, and ET-3) of naturally occurring polypeptides, with ET-1 being the most clinically pertinent isoform. ET-1 was formally identified in 1988, at which time it was viewed mainly as a potent vasoconstrictor; however, the biological understanding of endothelin has since rapidly evolved, and it is now appreciated that ET-1 is not only a potent vasoconstrictor...
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ژورنال
عنوان ژورنال: European Journal of Clinical Investigation
سال: 2009
ISSN: 0014-2972,1365-2362
DOI: 10.1111/j.1365-2362.2009.02123.x